Prion-like propagation of cytosolic protein aggregates
نویسندگان
چکیده
منابع مشابه
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.
Luminescent conjugated polymers (LCPs) interact with ordered protein aggregates and sensitively detect amyloids of many different proteins, suggesting that they may possess antiprion properties. Here, we show that a variety of anionic, cationic, and zwitterionic LCPs reduced the infectivity of prion-containing brain homogenates and of prion-infected cerebellar organotypic cultured slices and de...
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Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrP). Ligands that bind to PrP can inhibit prion propagation and neurotoxicity. Extensive prior work established that certain soluble assemblies of the Alzheimer’s disease (AD)-associated amyloid b-protein (Ab) can tightly bi...
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ژورنال
عنوان ژورنال: Prion
سال: 2009
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.3.4.10013